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Jacketed Liposome Extruder

Description: Genizer Jacketed Liposome Extruders is compressed air driven, temperature controlled, from testing to manufacture production of liposome and lipopolyplex for drug and gene delivery.
Catalog Number: Cat.GJE
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$3,000.00   Login for Discount
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  • Catalog No.:
    GJE-10mL GJE-100mL GJE-800mL GJE-3000mL GJE-10000mL
  • Gas Connection:
    CGA580 (USA) G5/8 (UK, CN) DIN477 (GE) NF E 29-650/C (FR) UNI4409 (IT)
  • Warranty:
    Standard 1 year 2 year 3 year 4 year 5 year
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  • Description
  • How to Use
Description:
Genizer Jacketed Liposome Extruders is compressed air driven, temperature controlled, from testing to manufacture production of liposome and lipopolyplex for drug and gene delivery. Homogenous samples can be produced quickly and easily in minutes; typically 5-10 passes are sufficient to produce a sample with uniform liposome size. The Jacketed Extruder is virtually no dead-volume and easily cleaned and suitable for sterilization. The Genizer Jacketed Liposome Extruders are designed to generate homogeneous unilamellar liposomes and Lipopolyplex. Extrusion is a one-step procedure that produces liposomes by forcing lipid suspensions of drug, protein or gene through track-etched filters with defined pore size. It is relatively gentle, exposing the formulation to moderate pressures up to 3,000 psi at controlled temperatures. The Genizer Jacketed Extruder is easily cleaned and suitable for sterilization, compliance with FDA and GMP sanitary standards in Pharmaceuticals.
 
Application:
Liposome Extrusion
 
Performance:
No Dead Volume
Jacketed Extruder can control the temperature of Extrusion
 
Specification
Catalog No. GJE-10mL GJE-100mL GJE-800mL GJE-3000mL GJE-13000mL
Sample Size 10mL 100mL 800mL 3000mL 13000mL
Cooling Jacketed Jacketed Jacketed Jacketed Jacketed
Dimensions 23cm×13cm×25cm 23cm×20cm×32cm 25cm×25cm×37cm 30cm×25cm×55cm 45cm×40cm×65cm
Weight 4kg 7kg 20kg 45kg 120kg
Min. Sample Size 5mL 10mL 120mL 800mL 2000mL
Application Liposome formulation up to production scale
Max. Pressure 3,000 psi-6,000 psi
Max. Temp. 80ºC (176ºF)
Power Type Compressed Gas
Nano-membrane Track-etched membrane
Cleaning Flush to clean/CIP/SIP
Sterilizing Whole unit autoclavable
 
Standard Features
Parts 1) Liposome Jacketed Extruder 2) 10 pieces of 130nm membrane
Feed Reservoir Temperature control jacketed cylinder
Inlet Type 1/4" High pressure coupling
Outlet Type 1/4" High pressure coupling
Nitrogen tubing G5/8" - 14 TPI BSP inlet Nitrogen High pressure soft tubing; adaptor with 3/8 inch male NPT and 1/4 inch female flare outlet
Nano membrane 130nm track-etched polycarbonate membrane
Compatibility Some Parts are compatible with Lipex™ in Northern Lipids
Product material 316L stainless steel, Viton
Material standard Pharmaceutical Grade; Compliance with FDA and GMP sanitary standards
Warranty 1 year against any manufacturing defects
 
Option Features
Detector Pressure gauge, Pressure transducer, Temperature transducer
Inlet Type Tri-clamp or Luer
Outlet Type Tri-clamp or Luer
Nano membrane 30, 50, 80, 130, 200, 400, 800nm, 1300nm, 2μm, 5μm, 10μm, 20μm, 30μm track-etched membrane (25mm, 47mm, 90mm, 160mm, 293mm)
Multi Extruder Parallel or Series connection of Multi Extruder
 
1) The Jacketed Liposome Extruder use the compressed air such as Nitrogen (N2) as the pressure souce


1. Add liposome membrane
2. Add the Liposome crude sample from the inlet
3. Connect Gas Connection with Regulator
4. Open the Nitrogen and pressure the Liposome crude sample through the Membrane

2) Please select the suitable Gas connection for your Nigrogen cylinder
 
CGA580  (USA) United States
G5/8  (UK,CN) United Kingdom, China
DIN477 (GE) Germany
NF E 29-650/C (FR) France
UNI4409 (IT) Italy

adaptor with 3/8 inch male NPT and 1/4 inch female flare outlet
Recommend Uniweld RHP400 Nitrogen Regulator
https://www.amazon.com/Uniweld-RHP400-Nitrogen-Regulator-Connection/dp/B008HQ6GXO?ref_=ast_bbp_dp

3) Warning

1) Always use Regulator, please get regulator from your gas supplier
2) Before open the extruder, be sure to shut down the Gas and open the Relief valve
3) DO NOT point the inlet of the Liposome extruder to any personnel and object which may induce the safety issue and property loss
4) The user should be  responsible for the violation of the clause and recommendation besides any other unsafe practices.