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Jacketed Liposome Extruder

Description: The Genizer Jacketed Liposome Extruder is compressed air-driven and temperature-controlled, from testing to manufacturing production of liposome and lipopolyplex, for drug and gene delivery.
Catalog Number: Cat.GJE
Price:
USD
$4,000.00   Login for Discount
Liposome_Extruder_English
Liposome_Extruder_English
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  • Catalog No.:
    GJE-10mL GJE-100mL GJE-800mL GJE-3000mL
  • Gas Connection:
    CGA580 (USA) G5/8 (UK, CN) DIN477 (GE) NF E 29-650/C (FR) UNI4409 (IT)
  • Warranty:
    Standard 1 year 2 year 3 year 4 year 5 year
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  • Description
  • How to Use
  • FAQ
Specifications
Description:
 
The Genizer Jacketed Liposome Extruders is compressed air-driven and temperature-controlled, from testing to manufacturing production of liposome and lipopolyplex, for drug and gene delivery. Homogeneous samples can be produced quickly and easily in minutes; typically 5-10 passes are sufficient to produce a sample with uniform liposome size. Genizer Jacketed Liposome Extruders are designed to generate homogeneous unilamellar liposomes and Lipopolyplex. Extrusion is a one-step procedure that produces liposomes by forcing lipid suspensions of drug, protein or gene through track-etched filters of defined pore size. The process is relatively gentle, exposing the formulation to moderate pressures up to 500 psi at controlled temperatures. The Genizer Jacketed Extruder offers virtually no dead-volume, is easy to clean, suitable for sterilization and in compliance with FDA and GMP sanitary standards in pharmaceuticals.
 
Application:
 
Liposome extrusion
 
Performance:
 
No dead volume
The Jacketed Extruder can control the temperature of the extrusion
 
Specifications
Catalog No. GJE-10mL GJE-100mL GJE-800mL GJE-3000mL
Sample Size 10mL 100mL 800mL 3,000mL
Cooling Jacketed Jacketed Jacketed Jacketed
Dimensions 23cm×13cm×25cm 23cm×20cm×32cm 25cm×25cm×37cm 30cm×25cm×55cm
Weight 4kg 7kg 20kg 45kg
Min. Sample Size 5mL 10mL 120mL 800mL
Application Liposome formulation up to production scale
Max. Pressure 80 psi-500 psi
Max. Temp. 80ºC (176ºF)
Power Type Compressed gas
Nano-membrane Track-etched membrane
Cleaning Flush to clean/CIP/SIP
Sterilization Whole unit autoclavable
 
Standard Features
Parts 1) Liposome Jacketed Extruder 2) 10 pieces of 100nm membrane
Feed Reservoir Temperature-controled jacketed cylinder
Inlet Type 1/4" high pressure coupling
Outlet Type 1/4" high pressure coupling
Nitrogen Tubing G5/8" - 14 TPI BSP inlet nitrogen high pressure soft tubing; adaptor with 3/8-inch male NPT and 1/4-inch female flare outlet
Nano Membrane 100nm track-etched polycarbonate membrane
Compatibility Some parts are compatible with Lipex in Northern Lipids
Product Material 316L stainless steel, NBR  or FKM
Material Standard Sanitary grade; compliant with FDA and GMP sanitary standards
Warranty 1 year against any manufacturing defects
 
Option Features
Detector Pressure gauge, pressure transducer, temperature transducer
Inlet Type Tri-clamp or luer
Outlet Type Tri-clamp or luer
Nano Membrane 30, 50, 80, 200, 400, 800nm, 1um, 2μm, 5μm, 10μm,  track-etched membrane (25mm, 47mm, 90mm, 142mm, 293mm)
Multi Extruder Parallel or series connection of multi-extruder
 
Product Introduction and User Guide Video Sharing:
Introduction of Jacketed Liposome Extruder

1) The Jacketed Liposome Extruder uses compressed air such as nitrogen (N2) as the pressure source.

The Jacketed Liposome Extruder uses compressed air such as nitrogen (N2) as the pressure source.
1. Add liposome membrane
2. Add the liposome crude sample from the inlet
3. Connect gas connection with regulator
4. Open the nitrogen and pressure the liposome crude sample through the membrane

2) Please select the suitable gas connection for your nitrogen cylinder
CGA580  (USA) United States
G5/8  (UK,CN) United Kingdom, China
DIN477 (GE) Germany
NF E 29-650/C (FR) France
UNI4409 (IT) Italy

adaptor with 3/8-inch male NPT and 1/4-inch female flare outlet
Recommend Uniweld RHP400 Nitrogen Regulator
https://www.amazon.com/Uniweld-RHP400-Nitrogen-Regulator-Connection/dp/B008HQ6GXO?ref_=ast_bbp_dp

3) Warning
Warning
1) Always use regulator, which can be obtained from your gas supplier.
2) Before opening the extruder, be sure to shut down the gas and open the relief valve.
3) DO NOT point the inlet of the liposome extruder at any person or object, as this could pose a safety risk or result in property damage.
4) The user must be responsible in the case of any violation of this clause and recommendation, as well as any other unsafe practices.

 
1. Liposomal Extrusion System for Jacketed Liposome Extruders. 



2. What is the drain disc?

The drain disc is made using PETE material and is used together with the filter membrane to avoid "pore blinding" or the obstruction of the capillary pores in screen membranes, which results in increased flow rates and throughputs.



3. Jacketed Liposome Extruders connected with chiller(circulator) for samples cooling or constant temp.

BTUs depends on temp desired and any other factor for the liposomesbeing extruded.